S2532

Immunoperoxidase staining of human tongue using Monoclonal Anti-S-100 (β-subunit), Clone No. SH-B1 (Cat. No. S2532).

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S2532

Sigma

 

Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse

clone SH-B1, ascites fluid

MDL number:MFCD00162834

Description

Immunogenbovine brain S-100b
SpecificityThis antibody recognizes an epitope located on the β chain (i.e. in S-100a and S-100b) but not on the α chain of S-100 (i.e. in S-100a and S-100ao). In ELISA, recognition of S-100 subunit by clone SH-B1 is independent of Ca2+. The product does not react with other members of the EF-hand family such as, calmodulin, parvalbumin, intestinal calcium-binding protein and myosin light chain. In immunohistochemistry, the antibody detects normal and neoplastic S-100 β subunit-containing cells (e.g. Schwann cells, chondrocytes, melanocytes, and melanotic tumors) in protease-digested, formalin-fixed, paraffin-embedded tissues.

Properties

antibody formascites fluid
cloneSH-B1 (monoclonal)
contains15 mM sodium azide
species reactivitysheep, rat, pig, goat, rabbit, feline, human, canine, bovine
application(s)dot blot: suitable using denatured-reduced preparations
 immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000 using protease-digested sections of human tongue
 indirect ELISA: suitable
 microarray: suitable
isotypeIgG1
Gene Informationhuman ... S100B(6285)
 rat ... S100b(25742)
shipped indry ice
storage temp.−20°C

Safety

WGK Germany3

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References

referenceHenriksson, J., and Tjälve, H., Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes. Toxicol. Sci. 55, 392-398, (2000) Abstract
 Inagaki, N., et al., Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. J. Neurol. Sci. 232, 59-63, (2005) Abstract